A Pharmacogenomic Basis for Tolerance of 5-Fluorouracil Following Early, Severe Toxicity from Capecitabine in a CDA ...
Introduction Capecitabine and 5-fluorouracil (5-FU) are fluoropyrimidines belonging to a class of antimetabolites. Capecitabine is an oral pro-drug that undergoes a 3-step enzymatic biotransformation to (5-FU), a process catalysed by carboxylesterase, …